MSE Seminar - Professor Mostafa El Sayed - Chemistry, Georgia Tech
Nanotechnology meets Biology in the Cancer Cell: Applications in medicine, drug delivery and determining drug efficacy.
A short introduction about the plasmonic gold and silver nanoparticles and plasmonic properties will be given.1 We then summarize the new properties of Gold when its size is reduced to the nanoscale. By conjugating small concentrations of gold nanoparticles to the nucleus membrane of the cancer cells we were able to record its SERS and/or its Rayleigh scattering images in the different phases of its full cycle2 , or as it dies if given cancer drugs3. This enabled us to follow the dynamics of drug delivery3 and measure the relative efficacy of different cancer drugs4, using either Rayleigh or SERS method of detection. Finally, the SERS technique was used in developing a simple method that enabled us to follow the time profile of the different processes involved in the mechanism5 of death of a cancer cell caused by use of a cancer drug.
1 S Eustis, MA El-Sayed, Why gold nanoparticles are more precious than pretty gold: noble metal surface plasmon resonance and its enhancement of the radiative and nonradiative properties of nanocrystals of different shapes, Chemical Society Reviews 35 (3), 209-217(2006).
2 B Kang, LA Austin , and MA El-Sayed, Real-Time Molecular Imaging throughout the Entire Cell Cycle by Targeted Plasmonic-Enhanced Rayleigh/Raman Spectroscopy, Nano Lett., 2012, 12 (10), pp 5369–5375.
3 B Kang, B., MM Afifi, LA Austin, and MA El-Sayed, M. A., Exploiting the Nanoparticle Plasmon Effect: Observing Drug Delivery Dynamics in Single Cells via Raman/Fluorescence, Imaging Spectroscopy. ACS Nano 2013, 7 (8), 7420-7427.
4 M Aioub, LA Austin, MA El-Sayed, Determining Drug Efficacy Using Plasmonically Enhanced Imaging of the Morphological Changes of Cells upon Death. J. Phys. Chem. Lett. 2014, 5 (20), 3514-3518.
5 B Kang , LA Austin , and MA El-Sayed, Observing Real-Time Molecular Event Dynamics of Apoptosis in Living Cancer Cells using Nuclear-Targeted Plasmonically Enhanced Raman Nanoprobes, ACS Nano, 2014, 8 (5), 4883-4892
Reception at 3:30 p.m. in the MARC Atrium